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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '66a55ee027c4214bde0a492f773bd74ed6e53b2873e0307b93987dbffe0a5cc8' 
  AND token = 'nqyBPWG7fPxNuZ8tD7TLjCJfJr7uOw2KOXso2aLlQTA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}