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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cd4250c03a40e168f89b601aadde69fab8c649065c4cb1022433456d0257e27c' 
  AND token = 'GVhH2cKh/eoaky9mZZ5Y7FThziIlBrTsuSMLEERMQZg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}