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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '527e6339021ba12de3d1af98d95a8d6f00165644ecffa22f704fc2f0db130ada' 
  AND token = '+D6XVEwxvfTMiyXfGCN4XsjdYlVHkK7DMlKUuMmTMPQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}