SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e1353df6ba7fda3567e3bd22549257fa6b2b6a295b8a4424f5c7a56c1557651' 
  AND token = 'QiSNgrtYNJmTFexre/K6wZAJrCFriA4CmedaYpG/1YY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}