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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2278ad9d1d27d4a74fc620086376406581d169ca149cda7b1b4c41ac31afe727' 
  AND token = 's5C+sVt3SqbANpPQbpwq6CIKX8nnw5J0cNGqnchwHKY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}