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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '301dc0ab58a21e6d018b798c57cec09df89b4fe2f49c8ba31922764e8f38d126' 
  AND token = 'hAe+Bb2+bQETTPBZwTwdw4PRAY3GYn+ItGH7bHndmxM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}