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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '039fcc5b3e6dbe368967a8b0407ab44cfc3f3e91ee02de08f688b97c5f16caeb' 
  AND token = 'DUm4t8Dnt+eT43upqQk1giZJZ3HZf22wK3JJ1mf1OfA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}