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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4153927ae6abbf22feb6ac8d5097acfa70a7d14f1218813eeec2278022016cb6' 
  AND token = 'izfyfK615Xhe+RymPmHkI9tHuEuWlfpj52zveNj4HUI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}