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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43ab95f3f2ef8d6727d05c9766e4b739a9dc34df7bdb0711b08db4000c2d573a' 
  AND token = 'pbZ19UHk/ceqt0SBy3MRLmYPwUdLj+T9dCpVqSqBz9c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}