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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4728aed6e661b2788d690986a518d983afa9e68e54ee8f2e47fabe656856a0c5' 
  AND token = 'Axx5Tyf9d/80+SaePeP2mSb6EhdUiLT/kRa0J7TswRw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}