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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b2191acb7459dc65ea0c2814f8d6f1b48fda194de81e759344105a384faf3c17' 
  AND token = 'oKV0mO2/nEM26Pf4TA7RwjtsXfn2CaTEcnQEbvVE4LI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}