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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '278e8017adf8b4c2197e7326446b77a19031528cb58f737e37ac9150cf28cdc9' 
  AND token = 'biZlRVYtdCTGj29ZoJEfRMPWa9bb4V8ep+68BWh9ZiQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00012

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}