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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2acb59cff1e2d812dc3098ddf63656e36cb20e9f3f406aee2793c17001dcd380' 
  AND token = '6f2QoY0aPe3xa+PmBDS3G2bODsQvHCJ8TcjYTeDL85U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}