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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1421448cdefc4bbdef0f1bf79e74d70bd5a325c9286be40b2de04c24c08789a2' 
  AND token = 'oU8bHXmgTGfmW2FwPhCHG2gmE8+msaG475PfE237GsI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00057

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}