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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c33e2e921657c78c331d7a3a791497bc5053b5308c13c429952790a73145905' 
  AND token = 'DunZsZpRShAqA5Hvpf2OEZzJP6Y3OjtABG23SGtaQCY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}