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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cea6b41e3e7e34e44971b48c1c62e34dce4355009b23aefd81c1bc77f59913e6' 
  AND token = '227OTpVEr0o+QQXAP4Hx4xFKZH27QoCd8zBQ8V0GCvg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}