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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b4ca85c3ac77124a4d4f94f43e2bb30e837ec4de19a330950b38fed2044b8ff' 
  AND token = 'Isa9IIiBCFXSrAKKq4UJp1M+ulCH7BPrlgNia8KvzAU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}