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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3c663bcd69302480e2f3f1ceab57a808053a88bb0af3eaf5f9e69caceefee9c0' 
  AND token = 'SbzKIO6KWfvbTshoWYUQVo1eV6520AK7wT9DeVg6XtQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}