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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c8e8ccefcd5de563c1220d3201a2b3b77df3fd73ad6e463d3ecb074b2df7f729' 
  AND token = '00eiURoz+SYWFLnQGDziRsYSqJL4Z4VdCxZfCpH2zJo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}