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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b21ecd1db5de588252a630522dd235e5e4ce98542b349160dbcf712019b50e5' 
  AND token = 'Ouq3PF1yaGvp0QStENAJgaLAC6GFv2qhWqbc8X23ypY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}