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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4b63a9a3871ed29c59b38b2822abc4e2e2a9b185cb13deba715e691fbf686b3' 
  AND token = 'JNOsqTK2YnVmpp1KpHmB4JMm6vPf+UVHF7cY3T7DqrM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}