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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '225f612f9c5a051de6580d15b24519d8251610530f0b8ef4aec061b916e21417' 
  AND token = 'jqdO/yW7NSNA+EEEKTqTGHAWS2MyLS3soYbcGChM7aQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}