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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6d59668f09b9d19254ab2fd202fd08b84a6161197ebe912ed49b056015ea4bc4' 
  AND token = '4AN+UB02xVwO36nbY08bXSQaVUFxQsF96LB0brSb6IA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}