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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7f27c12c6e268204d2666f026e3351e1ec1b2b551ab4be6a47eb6849ab474343' 
  AND token = 'OZ4c5NEOozwc+PPm6QV/vRBuV1ThsTiRUS1KNC6zPoU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}