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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '049d3a510e729d1f2b62ac8ee55611852075beac059d45bbf3b6e4d70fd36421' 
  AND token = 'omhPyFeBIBi20eUP9g91EWui/+n6UX9VXJPuwza8xC0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}