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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd433212c739a7c4dabc6b9a8c1644dc967e682713a0aa127046efbcaa4c0d708' 
  AND token = 'NFckessCN6Uli1p1TJ6IVB5F4hYGVZCpIiX2N7qchbQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}