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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '450e12aa9960e741684ff6bbf2a46dbbfc484540c51eb774d089f0333e7bf68c' 
  AND token = 'u3UWPyk/iX6iuzIE6M0vu8ShEIPfRIE3ZbD0JtomtmI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}