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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7e486c8f52c3d8c36142e13b78d0e6069677b6fc0a6641defedd8fb401bc8cf4' 
  AND token = 'edbxPD5qRQ7Zkv+lzPtNpsXCBBEEVdPmWjiu0K6OuDM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}