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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21e233e85026bb469c509c5c11d4115739b2829f5a6484bb310a00506dead1f7' 
  AND token = 'sS/xqQ/DNXS4DlJEuwf9KDfx1ldZL+cYfo2ocZLmmtg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}