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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22ef721498b1f9200774ad28890f8ae3121c78acad61e939c051d4fc23668381' 
  AND token = 'v/hICLNKm/2057F2EsTJjfgtE1B4WX8nVYKnNT4Qi+Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}