SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49dbb1c78bf421126fc9fa91139035cb1c91db3defc258b2e1719d3fdc33d706' 
  AND token = 'WUpRoV8sp9J6E6RKgSprhqj/eJ7CpHGQ+Z+dq2JCDA8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}