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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25509d52ad41a109f3bf82dbd1b0ab46cc95e1aae9056cb0de879e4e453b5f61' 
  AND token = '1qRPuAFB+fVuWZuoVlB/ma66MF0eds68dD5+EsRWfi8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}