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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd250e04c41b86cdbc0387f6416bba49dbbe71456a0927b7e664bbc263a872401' 
  AND token = 'lza1b7fRA25SqMtiBdFpiBLPBNFhKN3rOVeQvBHdTeo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00054

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}