SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed4285ddd8d76a7af5918f8f1f2990cf2a937fd5de820b606ea663f357b5f2b4' 
  AND token = 'RV2hbvZZXAQ1wgNfIgODY20klyq7kwCQGTkkRHODvFg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}