SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e2cbc4ad05c4e6e418c88c0fe5f5eb8c05d8249b2dd3558653abde8b73c9579b' 
  AND token = 'UTmBe9XhrIdZkNaDKbJH0f0sHpWhsdaUWX+yew8Y61w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}