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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59f5dddedc24ac2709644027a2f45c1e1bb7b162e9e140e712ee080ddfb33498' 
  AND token = 'WDzaJywBXBnE/seoBBt1QSObSSlBpkPZOyNUnTG4RXM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}