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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '427e822f33b6c2fc09c1d03330f3a1d9d391da5fdb804ff0c52a957a4b21b4b7' 
  AND token = 'oi5qQbmCdBlposykMu6I4yKYs7/bFzd+VhGXYI26EGI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}