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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a647f4fa50fab5bd041983f8f96c16fc276254b19e2e9c197d0c75e2bdf26380' 
  AND token = 'QKuFe/OezR/t+NAok9akOIgV8bqh9UjuqLhe2oKndLU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}