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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '225c7711b7da5cc5ad6a92244d7e13581d57e11421454ceccbf37bcdd9d5603f' 
  AND token = 'JtUwYY4tPcysrE0g3A4ml9yb3RjnUM/NP4lggq/e8HM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}