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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'df311440460940154f5be855d198fe857fcbbf318249b5601c1d1cb34182e319' 
  AND token = 'xPW/FOg49U2JTRmKao6BlJlT76M2yuTH2d9MTi8S1oQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}