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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b4c644f9c7838a6ae8322b5e3ee9627d65c576edd5383e1884251d416ef3c64b' 
  AND token = 'Glw3++KEoKPS70qa1U5vAkuuabWQA3BeGYRr8SYHFPQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}