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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78921b75c9c39f75a47ca9c3c6530b9a2c21b89d0e9d0451f85af3e169e992f7' 
  AND token = 'UShSkV/YWwj5bB1l+8+GIm0tiQkFBQS8T2rzi9HmfeQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}