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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b45fa823d1d1ea62f769cdaad43c4270807b3f886ea4a27ca73aeb8b7d35ea97' 
  AND token = 'MsI+cD6A/HesvqBFbmZpfa0RB/TQeCa7P3JLzfXIrlY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}