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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6272de87bbf566af0eab7edf406de4dc27fa13cb89feaea665e3431d2b03aa60' 
  AND token = '+z+WVJdOhMN2fFiHJCE3kou7EpjWyan3zyzOTtWXsr4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}