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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45cf0d4c7288e8fe6792ca27d68e31c35096def1649467e06913bcfc1b07bed9' 
  AND token = 'HQYXsL9UpKRBdTnTog2c/klakLpAN43x+UVfX5rQRts=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}