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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cc870aa82bc03c08a570495401e5901260d492bb3809001a3636a64e7fc9168b' 
  AND token = 'qqJHu3aC9BlW6Zeal+Mi+hGTduF7ouZQmc7NacUTXz4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}