SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2ca9e43ae4cb45d326f908efd9063034e53291db25c4da12249c23831efaa4e2' 
  AND token = '/oWBB3WXUp6gHW0RGpsTpqMzRcoD16aBpHtVTFJ4HFg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00012

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}