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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '263f7a27d092cb884a328e8077b76802b111b841691052e6efe35e0474a8ceca' 
  AND token = 'Gp0bxUAJa6pNDx+CTZHQA7M04e3hhwM8E429Sh0C0mQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}