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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0f3fa48c1164061a0addba58ad1313cfcb2d8a8031dd76b9c765e310519d4f3a' 
  AND token = '9gRHCAUzRbi2x2+mz6O7JjBeHPuIOYe4u1tmXB0bD7A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}