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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f59750ef44e38f60c20683da50f299549be339ce97f88a2b29d88f013cff2f06' 
  AND token = 'APxNjOZlTC1sjumiglYuo/VWZLcP/fJ0H+sP6FoKj00=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}